LEUCOMYCIN V 3,4B-DIPROPIONATE
medemycin
CAS: 35457-80-8
Molecular Formula: C41H67NO15
LEUCOMYCIN V 3,4B-DIPROPIONATE - Names and Identifiers
LEUCOMYCIN V 3,4B-DIPROPIONATE - Physico-chemical Properties
| Molecular Formula | C41H67NO15 |
| Molar Mass | 813.97 |
| Density | 1.1651 (rough estimate) |
| Melting Point | 155℃ -156℃ |
| Boling Point | 874℃ |
| Specific Rotation(α) | D23 -67° (c = 1 in ethanol) |
| Flash Point | >110°(230°F) |
| Water Solubility | Soluble in methanol or ethanol. Insoluble in water |
| Solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 6.9 in 50% aq ethanol |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Refractive Index | 1.6220 (estimate) |
| Use | Mainly for Gram-positive bacteria and meningococcal, gonococcal Gram-negative bacteria with antibacterial activity |
| In vitro study | Midecamycin inhibits the majority of streptococci , staphylococci , and strains of Haemophilus and Listeria at concentrations of less than 3.1 μg/mL. Midecamycin is a 16-membered macrolide. Midecamycin is a new macrolide antibiotic, which is produced by Streptomyces mycarofaciens . |
LEUCOMYCIN V 3,4B-DIPROPIONATE - Risk and Safety
| RTECS | OH4730600 |
LEUCOMYCIN V 3,4B-DIPROPIONATE - Upstream Downstream Industry
| Raw Materials | n-Butyl acetate Dextrose Anhydrate |
LEUCOMYCIN V 3,4B-DIPROPIONATE - Reference Information
| overview | midecamycin is a macrolide antibiotic produced by streptomyces. The antibacterial performance is similar to that of erythromycin. Medecamycin acts on the 50S subunit of the bacterial ribosome and hinders the synthesis of bacterial protein. It is a long-term antibacterial drug. |
| pharmacological effects | medetomycin is similar to erythromycin in antibacterial spectrum, has good antibacterial effects on gram-positive bacteria and Neisseria, and has effects on non-producing Staphylococcus aureus, Staphylococcus epidermidis, pneumococcus, hemolytic streptococcus, diphtheria bacillus, pertussis bacillus, mycoplasma, etc. Bacteria have cross-resistance to this product and erythromycin, and some erythromycin-resistant Staphylococcus aureus are still sensitive to this product. |
| preparation | 1) first adjust the midecamycin fermentation broth to acid, filter with a ceramic membrane filter, after the filtration is completed, use 1 to 2 times the volume of pH has been adjusted to 4.0 to 5.0 purified water solution top water, all the filtrate is collected; 2) adjust the above filtrate to alkaline, add butyl acetate for extraction, the volume of butyl acetate is the filtrate volume of 10% ~ 15%; 3) transfer the above extract to the acid solution; 4) adjust the pH of the phase-changing solution to 8.0~8.5 through the alkaline solution, and add butyl acetate with 10% ~ 15% as the phase-changing liquid volume to extract at 45~50°C to obtain the extract, and then gradually drop purified water with pH of 6.0~8.0 at room temperature until a large number of crystals are precipitated; 5) After the crystals are separated by a centrifuge, wash the crystals with a butyl acetate solution with a moisture crystal mass of 1~2 times the volume 50% concentration, and dry to obtain a finished product of midecamycin. |
| Biological activity | Midecamycin is an acetoxy-substituted macrolide antibiotic that can target Gram-positive and negative bacteria. |
| target | Antibacterial |
| use | mainly has antibacterial activity for gram-positive bacteria and gram-negative bacteria such as meningococcus and gonococcus |
Last Update：2024-04-09 21:21:28
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CAS: 35457-80-8
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Product Name: Midecamycin Request for quotation
CAS: 35457-80-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 35457-80-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Midecamycin Visit Supplier Webpage Request for quotationCAS: 35457-80-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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Raw Materials for LEUCOMYCIN V 3,4B-DIPROPIONATE